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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Do Tramadol, Celebrex And Paracetamol Cause Serotonin Syndrome?

I am currently on the following prescribed meds: Tramadol (2x 200mg daily);Celebrex (2x 100mg daily); Omeprazole (1x 20mg daily); Paracetamol (6-8x 500mg daily); Seretide (2x 250mg daily). Can you please advise if you would expect someone to experience symptoms of Serotonin Syndrome with the above combination of meds? Thank you
Mon, 14 Sep 2015
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General & Family Physician,  's  Response
Hi & Welcome.
I appreciate your concern for the possibility of Serotonin syndrome while taking the prescribed medications.

Yes, one of the prescribed medication (Tramadol) can cause Serotonin syndrome.

Serotonin syndrome is a drug-related complication that results from increased brain-stem serotonin activity, usually precipitated by the use of one or more serotonergic drugs.

Tramadol is an analgesic medication with predominantly opioid like activity and it affects serotonin and norepinephrine levels in the brain.

Although you have been prescribed pain killers like Paracetamol & Celebrex, so Tramadol should be avoided to prevent this dangerous drug induced complication.

Best wishes.

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Do Tramadol, Celebrex And Paracetamol Cause Serotonin Syndrome?

Hi & Welcome. I appreciate your concern for the possibility of Serotonin syndrome while taking the prescribed medications. Yes, one of the prescribed medication (Tramadol) can cause Serotonin syndrome. Serotonin syndrome is a drug-related complication that results from increased brain-stem serotonin activity, usually precipitated by the use of one or more serotonergic drugs. Tramadol is an analgesic medication with predominantly opioid like activity and it affects serotonin and norepinephrine levels in the brain. Although you have been prescribed pain killers like Paracetamol & Celebrex, so Tramadol should be avoided to prevent this dangerous drug induced complication. Best wishes.