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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Serotonin Syndrome?

hI! mY NAME IS BARBARA. MY HUSBAND IS CURRENTLY TAKING A GENERIC FORM OF wELBUTRIN AS WELL AS CYMBALTA, ON THE ADVICE OF HIS PSYCHIATRIST. HE TAKES , FENTANYL PAIN PATCHES AS WELL, FOR CHRONIC PAIN. IS ALL OF THIS TOGETHER SAFE? I RECENTLY HEARD ABOUT A SERATONIN SYNDROME THAT SOUNDS SCAREY! I WOULD LIKE TO KNOW MORE ABOUT IT! mY EMAIL ADDRESS IS YYYY@YYYY THANK YOU!
Wed, 30 Sep 2020
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General & Family Physician,  's  Response
Hi,

Welbutrin contains Bupropion used as an antidepressant. It acts by enhancing the action of Dopamine and Norepinephrine by increasing neuro-transmission and inhibiting re-uptake of Dopamine and Norepinephrine. Side effects are nausea, vomiting, dry mouth, dizziness, constipation, headache, etc.

Cymbalta contains Duloxetine prescribed as an antidepressant. It acts by Serotonin and Norepihephrine reuptake inhibition. Side effects are nausea, dry mouth, constipation, headache, etc. Serotonin syndrome is the condition in which the serotonin levels in the brain get increased and disturbs the mood. Mild symptoms are diarrhoea and shivering. Severe symptoms are agitation, restlessness, increased heart rate and blood pressure, loss of muscle coordination, muscle rigidity, etc.

Very severe symptoms are high fever, irritability, irregular heart beat and unconsciousness. If not treated on time, it may lead to death. Both Welbutrin and Cymbalta has side effect of serotonin syndrome. Regular check up helps to control the chances of serotonin syndrome. Symptoms should be observed for the possibilities of serotonin syndrome.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Pradeepraj, General & Family Physician
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What Causes Serotonin Syndrome?

Hi, Welbutrin contains Bupropion used as an antidepressant. It acts by enhancing the action of Dopamine and Norepinephrine by increasing neuro-transmission and inhibiting re-uptake of Dopamine and Norepinephrine. Side effects are nausea, vomiting, dry mouth, dizziness, constipation, headache, etc. Cymbalta contains Duloxetine prescribed as an antidepressant. It acts by Serotonin and Norepihephrine reuptake inhibition. Side effects are nausea, dry mouth, constipation, headache, etc. Serotonin syndrome is the condition in which the serotonin levels in the brain get increased and disturbs the mood. Mild symptoms are diarrhoea and shivering. Severe symptoms are agitation, restlessness, increased heart rate and blood pressure, loss of muscle coordination, muscle rigidity, etc. Very severe symptoms are high fever, irritability, irregular heart beat and unconsciousness. If not treated on time, it may lead to death. Both Welbutrin and Cymbalta has side effect of serotonin syndrome. Regular check up helps to control the chances of serotonin syndrome. Symptoms should be observed for the possibilities of serotonin syndrome. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Pradeepraj, General & Family Physician