Do natural histamines cause inflammation in the body, and consequently taking anti histamines act at reducing inflammation ? I have had several tick bites over a period of 20 yrs with only local swelling & inflammation, but the last two bites have caused much more severe ( anaphylaxis) with more extensive swelling near bite site, swollen lymph nodes,body hives , strong pain at the bite site, drop in BP, Is it safe to take extra anti histamine ( double or more of normal dose) if I get another tick bite? Will the next tick bite necessarily cause a more severe reaction?