Hello and Welcome to 'Ask a Doctor' services:
I have reviewed your query and this is my opinion.
The first thing that struck me was why was she taking
oxycodone with
methadone when the two together are synergistic for
drowsiness and confusion? Would that not be the first thing one would think of before looking at her vitamins? Then, combine that with a muscle relaxer like
Tizanidine and there is the question of whether she was medically fit to drive or even be able to coordinate her activities with such a prescriptive cocktail.
Nitrates increase cognition, not decrease it. Nitrates increase blood flow, not increase confusion and
disorientation nor do they cause seizures. To answer your question specifically, one should go to the company the vitamins were obtained from and request any clinical studies they have on the vitamins in question and ask for any side effects identified to date in animal or human subjects taking these supplements. They may or may not have anything to help you.
In reviewing this case in its entirety these are the priority concerns:1) the number of synergistic medications currently being taken and their cumulative side-effect risk profile which may include seizures; 2) the fact that the woman sustained a closed
head injury for which she had no evaluation or treatment for and 3) finally, a potential but improbable link to recent vitamin intake.
I hope my answer gives clarity to the situation in question and it is my opinion that in this case the vitamins had nothing to do with this incident.
Warm Regards,
Kathy Shattler, BS, MS, RDN