Can accupril 10 mg cause chronic bowel irritation that results in watery stools? I stared take Zesteril 10 mg and used it many years (5-6) then switched to Accupril about 3 years ago. I worked for Pfizer and they supply Pfizer drugs free to retirees. The watery stools symptom started in January this year. It started as occasional watery stools and when a BM is needed, there is no warning to find a commode immediately. There is no blood in the stools (checked by my doctor in March). That isymptom s annoying. I saw my my gastroenterologist in September-October and he suggested I take Immodium 2 mg in the AM to see if it helps. It does, but not stop the watery stools. I take Toujero and Victoza injections in the AM and 2x a day metformin 1 gm each dose. I also take lipitor 10 mg daily. I am a male 78 years old.