Hi Bumetanide is a potent diuretic that causes a profound increase in urine output by preventing the kidney from retaining fluid. Specifically, it blocks the reabsorption of sodium and fluid from the kidney s tubules. It is in a class of loop diuretics which also includes furosemide (Lasix) and torsemide (Demadex). One mg of bumetanide is approximately equivalent to 10-20 mg of torsemide and 40 mg of furosemide. Persons with nephrogenic diabetes insipidus will need to consume enough fluids to equal the amount of urine produced. Correct any underlying cause such as hypercalcemia. The first line of treatment is hydrochlorothiazide and amiloride. Consider a low-salt and low-protein diet. Thiazide is used in treatment because diabetes insipidus causes the excretion of more water than sodium (i.e. dilute urine). This condition results in a high serum osmolarity . This high serum osmolarity stimulates polydipsia . However, since the patient is unable to concentrate urine to excrete the excess solutes, the resulting urine fails to decrease serum osmolarity and the cycle repeats itself, hence polyuria. Thiazide diuretics allow increased excretion of Na+ and water, thereby reducing the serum osmolarity and eliminating volume excess. Basically, Thiazides allow increased solute excretion in the urine, breaking the Polydipsia-Polyuria cycle. So a person with nephrogenic DI needs a diuretic ,preferably thiazide. So please consult your doctor and discuss with him.