What side effects can Bupropion cause when mixed with Prozac? Bupropion was added to the RX's I take about a month ago. Now I seem to be doing some strange things that's only begun since then. For instance, starting to talk out loud in the middle of a sentence that I'd just been thinking about. Yesterday I tried taking a drink of water out of a glass with a spoon. I had neither a glass or a spoon! This is getting scary. Can Bupropion cause this type of thing when mixed with other mess?