I take depakote ER, 250 mg a.m. and 500 mg h.s., and have symptoms that concern me. Can depakote cause an irritation of my stomach lining? I recently had an upper endoscopy and there is an ulcer in my stomach; although I took prescription strength omeprazole (spelling?) for 30 days, the ulcer is still surrounded by inflamed tissue. In addition, I have extremely dry mouth, and my mouth tastes like bile. When I have the urge to urinate, there is little volume output. I have severe neck pain, and have been seeing a physical therapist.