Hi, Thanks for posting in HCM. I understand your concern. Depo-Provera contains medroxyprogesterone , which is a derivative of hormone progesterone. Medroxyprogesterone acts as a contraceptive as it inhibits the secretion of pituitary gonadotropin which, in turn, prevents follicular maturation and ovulation. Side Effects which may be associated with its use include: Irregular menstrual periods, or no periods at all, Headache, Depression, Dizziness, Acne, Changes in appetite, Weight gain, Unwanted facial and body hair, Hair loss and Loss of bone mineral density. Change in the menstrual cycle is the most common side effect. You may have irregular bleeding or spotting, particularly in the initial few months. After a year of use, about 50% of women will stop getting their periods. Their periods usually return when they no longer get the shots. Long-term use of Depo-Provera may lead to loss of bone mineral density, which makes osteoporosis more likely. This risk is greater if it is taken for longer than 2 years, with associated risk factors like alcohol intake and smoking. Hope the information provided would be helpful. All the best.