Hi, I have been diagnosed with UC about 14 years ago, was treated successfully and it went into remission. 2 years ago I had a bowel obstruction, hospitalized 3 weeks, removal of cecum & some bowel removal. 6 months later had another BO, surgery but no resection. Since then have had continual problems with diarrhea (unmanagable & explosive) at first every day, then every 2-3 days. Started sulfasalazine (again) 6 months ago, and now (finally) episodes are about 7-10 days apart. Having more problems with weight gain,up about 10-15 lbs! I exercise every day and following a Paleo diet, but not seeing any improvement with my weight. Does the sulfasalazine cause weight gain? I also take Zantac 2xdaily for heartburn & thyroxin. Would appreciate if you can help Many thanks, Kate