I have high blood pressure and taking Terazosin, Atenenol, Diltiazen, a Mononitrate, and Losartin for about 25 years. I m now suffering from a reduced kidney function (Glomular flow rate of about 45). I am 77 years old, have had bypass heart surgery (1984), and three stents, and three caratoid surgeries. I am to have a heart cath and additional stent this week. Main question at his moment is: Which of these meds may be causing kidney disease? I am in borderline stage 4 kidney failure. My doctor just took me off diltiazem and reduced the losartan to half of a 25 mg tablet. I have had some occasions of low blood pressure in the range of 85 over 45. I have generally had BP in the range of 110 over 60. My general concern are the kidneys and the meds that I am taking. I was a smoker previously, but have not smoked for the last 15 years. I am at 150 pounds (5 7 ) and look healthy and trim. I try to exercise, but get tired easily and have been getting angina pain easily. I use nitroglycerin two or three times per week. Ethan