Husband is on Zestril 20 mg. and Amlodipine 10 mg. for high BP. BP was slightly elevated, so his Dr. told him he could increase the Zestril to 30 mg. qd. The last few weeks he has suddenly developed hives on his back, lower abdomen, and groin area at times. It seems to be getting worse tonight. Took two Benadryl 25 mg. and seems to be relieving the itching and the hives are somewhat better. We have tried changing soaps, watching what he eats, and making sure we had no bugs. Can the Zestril cause hives? This seems like the only answer is the Zestril causing the hives.