Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Zoloft is composed of Sertraline, which is an antidepressant belonging to a group of drugs called selective serotonin re-uptake inhibitors (SSRIs). Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). Signs of an allergic reaction side effects like skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat needs to be attended on emergency basis. You need to report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Since you are experiencing severe fatigue and sleepiness, it would be better to consult your doctor for proper evaluation and appropriate management. Hope I have answered your query. Let me know if I can assist you further.