I had a total hysterectomy in June of 2012 and have NEVER felt right after . I developed a blood clot in my right mid calf 6 mo after surgery and was on warfarin for 6 mo . Due to a vacation planed for the following June I stayed on it until I got back from Italy. While ther my legs became very swollen and upon returning to the USA was checked out in the er no dvt in my leg but they missed a pe in my pulmonary artery. Total time on warfarin 9 mo. Thinking things would get back on track they put the blame on estrogen therapy. I still have not felt right and have started with a lot of back pain joint pain and muscle fatigue. I was told to try adding more biotin to help with my muscle pain and knee pain. I used to work out for two yards with a personal trainer and walk 3 miles a day. I keep telling my doctor or pa that when I walk now I pay for it with stiff legs and knee and foot pain. Yesterday I went to the er because I could not stand the burning sensation behind my upper right thighs and right calf. Yep another blood clot in the same place!,, no estrogen this time, can my body be rejecting the mesh used as a bladder sling?