Hi, Yes, a colon infection can lead to nausea, anal itching, and heartburn. The symptoms of a colon infection can vary, but common symptoms include abdominal pain, diarrhea or constipation, fever, and nausea or vomiting. Anal itching can sometimes occur due to irritation or inflammation of the skin around the anus caused by frequent bowel movements or diarrhea. Heartburn can also be a symptom of a colon infection or inflammation, as it can cause reflux of stomach acid into the esophagus. Additionally, certain medications used to treat colon infections, such as antibiotics or proton pump inhibitors, can also cause heartburn or other gastrointestinal symptoms. It is important to follow the treatment plan prescribed by your healthcare provider and to see a GI doctor for further evaluation and management of your symptoms. They may recommend additional tests or treatments to help manage your symptoms and prevent complications. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician