I am an eighty- two year old woman, and am concerned about things I hear regarding Nexium usage. I have talked with my family physician regarding long-term usage; her answer is always, Do you still have a hiatal hernia? Of course, the answer is, Yes ! I go every four months for routine blood tests; I get good good reports for someone my age. My kidney function is 55%, liver enzymes good, cholesterol levels good, blood count was normal at last check three months ago. No known heart problems. Do I have reason to be concerned about the effect of long-term usage of Nexium for acid reflux? I have used it since it came on the market.