Does Lidocaine/ketamine Infusion Create Irrational Behavior As Side Effect?

my friend has CRPS and recently (last week) went through 3 day out patient lidocaine Ketamine infusion treatment- which by all accounts were successful as her pain level is down, however, she seem to have spiraled into an unexplained emotional roller coaster. She has become confrontational with her husband and very argumentative, this behavior is not her- I have seen her over the past couple of days and she s shared with me why she s upset with him, but to me, the reasons are trivial and I believe that she is unaware of reality.... she is now texting me saying she doesn t understand what is happening (their arguing).... my question is, would the lidocaine/ketamine infusion create this type of irrational behavior as a side effect?