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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Melagin For Vitiligo Cause Side Effects?

Area around the white spot (vitiligo) on my hand has started losing pigmentation. I have been prescribed -Melgain to be applied at night, Tenovate i the morning after bath and Crolim in the afternoon. Is it because of side effect of one of the medicines, as only the area where I apply medicine has getting affected?
Thu, 6 Nov 2014
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Dermatologist 's  Response
Hello. Thanks for writing to us at healthcaremagic

It is possible that vitiligo patch is expanding and therefore the treatment needs to be modified or changed.
Another possibility is that the super-potent steroid present in Tenovate cream i.e clobetasol propionate 0.05%, is causing surrounding hypopigmentation; this is one of the known side effects of potent topical steroid applications, specially if used over a longer duration.
However, these 2 possibilities can only be differentiated on physical examination: while vitiligo causes total loss of pigment, hypopigmentation related to super-potent steroid applications is not complete.

I usually start my patients on a moderately potent steroid like mometasone furoate 0.1%, rather than a super-potent steroid like clobetasol propionate.
I will suggest that you seek another appointment with your dermatologist for a confirmatory diagnosis and any modification of treatment, if needed.

Regards
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Does Melagin For Vitiligo Cause Side Effects?

Hello. Thanks for writing to us at healthcaremagic It is possible that vitiligo patch is expanding and therefore the treatment needs to be modified or changed. Another possibility is that the super-potent steroid present in Tenovate cream i.e clobetasol propionate 0.05%, is causing surrounding hypopigmentation; this is one of the known side effects of potent topical steroid applications, specially if used over a longer duration. However, these 2 possibilities can only be differentiated on physical examination: while vitiligo causes total loss of pigment, hypopigmentation related to super-potent steroid applications is not complete. I usually start my patients on a moderately potent steroid like mometasone furoate 0.1%, rather than a super-potent steroid like clobetasol propionate. I will suggest that you seek another appointment with your dermatologist for a confirmatory diagnosis and any modification of treatment, if needed. Regards