Does a negative IBD panel always rule out Crohn s? Colonoscopy showed congested, erythematous, hemorrhagic, inflamed, and ulceration in the terminal ileum. Upper GI and small bowel follow through showed a small section of narrowing at the end of the small bowels. Curious as to whether they use imaging and the scope, along with biopsy showing ileitis to diagnosis or say no IBD based off of a negative IBD panel?