Hello, Tamoxifen is what we call a selective estrogen receptor modulator. Tamoxifen has been associated with rare instances liver injury, typically arising within the first six months of treatment and having variable presentations with elevated liver enzymes. Tamoxifen therapy has also been linked to the development of fatty liver.Serum aminotransferase elevations and fatty liver generally improve once tamoxifen is stopped, but the improvement may be slow. Your doctor will keep a close eye on the liver enzymes and should be able to manage you without any problems. Do note that, hormones are naturally occurring and they will cause problems only when in excess. So, if your good doctor keeps a close eye on things, you shouldn t worry too much. Hope I was able to clear your doubts. Do get back in case I can assist you with anything else.