Hello I share your concern and that ks a lot for derailed medical history Looking at your history this could be breast cancer or allergy/inflammation of ducts and areola I would like to know whether you can feel any lump or swelling within th breast is it in both the breasts or in one side only History of smoking with tubal pregnancy and your age makes it high probability for a breast cancer In my opinion you should consult a general surgeon for check up and a battery of investigations like mammography and USG breast to confirm/rule out the both the conditions You should quit smoking now Have good balanced food with multivitamin supplements Maintain good hygiene I hope you will find my response relevant to your query Thanks for using our services Best wishes