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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does The Development Of Rhogam Mean Erythroblastosis Fetalis Is No Longer Seen?

1.     Prior to the development of Rhogam, a woman with blood type O- giving birth to a baby with blood type A+ had a 2% chance of developing an immune response and producing anti-Rh antibodies. A woman with blood type A- giving birth to a baby with blood type O+ had a 16% chance of immune response. Why do you think there such a large difference in risk? Why was the risk not higher in either case? How does Rhogam decrease this risk? Does the development of Rhogam mean erythroblastosis fetalis is no longer seen?
Mon, 20 Jul 2015
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Hematologist,  's  Response
Hi, dear
I have gone through your question. I can understand your concern.
When rh negative mother give birth to the rh positive baby there is chance of erthroblastosis fatalis. But it occur with second exposure. When first time rh positive rbcs come in contact with maternal blood it will produce anti rh antibodies. These antibodies later cross the placenta and react with fetal rbcs and produces hemolysis. ABO blood group has Ig M type of antibodies so it has low chance to cross placenta. This is the reason.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
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Does The Development Of Rhogam Mean Erythroblastosis Fetalis Is No Longer Seen?

Hi, dear I have gone through your question. I can understand your concern. When rh negative mother give birth to the rh positive baby there is chance of erthroblastosis fatalis. But it occur with second exposure. When first time rh positive rbcs come in contact with maternal blood it will produce anti rh antibodies. These antibodies later cross the placenta and react with fetal rbcs and produces hemolysis. ABO blood group has Ig M type of antibodies so it has low chance to cross placenta. This is the reason. Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.