Hi Doctor, This is Regarding my Mother. She earlier had Plasmacytoma which progressed to Multiple Myeloma . I have asked questions and uploaded reports earlier and Dr. Indranil replied with his advice which guided us alot. She had fracture in spine which was treated with kyphoplasty and last skeletal survey revealed some small leisions in skull and decease was considered as Multiple Myeloma. She is currently undergoing Chemotherapy (Bortezomib-Dexamethason). 2 cycles (with 4 injections\cycle) are completed and 3rd cycle is going on. We got SE test done after completion of 2nd cycle which revealed M-spike to be 0.86gm\dl that is much reduced as compared to last SE report, that was done before starting of chemotherapy (where M-spike was 3.02 gm\dl). Doctor here are suggesting for Stem cell trasplant. They are leaving the decision on us and have said that she may go with stem cell transplant after M-Spike reduce to 80% from its current value which is 0.86 gm\dl. But, my Mother does nt want to go with Stem cell Transplant as she fears from its side effects and doesn t wants to reduce the quality of life because of its side effects. Please give us best possible decision at this time as we are really confused for next step after chemotherapy. Thanks and Regards, Bhuwan Grover