Hi d.angelz, Thanks for posting your query. The isotretinoin is a vitamine-A analogue and it is primarily used in the treatment of nodulocystic acne and it is a known teratogen so pregnancy must be avoided during its s use and 6months following the cessation of treatment. The depressive episodes you are having is related to it for which you should consult the treating physician, who would titrate the dose. The vaginal dryness is expected with isotretinoin use and should not stop you from enjoying sex. Use KY Jelly liberally to lubricate and the problem would be solved. The side effect profile of isotrenoin is dryness of mucous membranes, dryness of skin with scaling, fragility, erythema, cheilitis, pruritus, epistaxis, conjunctivitis, dry sore mouth and palmo-plantar exfoliation, dry eyes, visual disturbances, skeletal hyperostosis and musculoskeletal symptoms. Elevation of serum triglycerides, LFTs, ESR and blood glucose. Hair thinning, photosensitivity. GI disturbances, hepatitis, Headache, drowsiness, sweating, mood changes, psychotic symptoms, depression, suicidal tendencies, benign intracranial hypertension, seizures. Vasculitis, hypersensitivity reactions, IBS. Potentially Fatal: Anaphylaxis. Haemorrhagic pancreatitis. Hope I have answered your query. If you have any questions I will be happy to answer. Please close the query if you have no other questions. Wish you a good health.