HI , I have been on a course of Methoextratre 1mg for approximately one year and I recently experienced symptoms similar to a urinary tract infection. I took a course of ammoxcilian for the UTI (I have a script at home for such occasions as this has happened to me before) it eased the problem but it did not go away completely so I went to DR who prescribed another antibiotic - Amiotil? took the course for week, and when that didn't work I was prescribed another antbiotic. After taking the third antibiotic for 2 days I felt that unwell like I was being poisoned! Some of the symptoms: throbbing & swelling of both feet, itchiness and aches and pains all over body and a terribly sore tongue) none of the usual remedies I use to cure my tongue helped and as a matter as fact the made it worse! SM33 or Kenologue. The only thing that has helped Nilstat drops four times day and stop taking the antibiotics. I was supposed to take today 10mg Methelextrate along with 10 mgs Prednislinone but I did not take the Methelextratre because I am worried that that may have caused the severe reaction to the Antibiotics. I am also on Letrosol for Eostrogen reductionand 40mg Nexium per day.