Sign-in to Ask A Doctor - 24x7
OR
Sign in with GoogleGet your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
Have Advanced Liver Mets + Jaundice From HER2+ Metastatic Breast Cancer. On Herceptin,carboplatin. Causes For Increase In Bilirubin?
Advanced liver mets + jaundice from HER2+ metastatic breast cancer. 2 weeks ago SGOT- 650, SGPT 350, Bilirubin 18.
Now SGOT- 390, SGPT 190, Bilirubin 24. Patient on weekly Herceptin (150mg)+ carboplatin (100mg) dose since 2 weeks. Taking ciprofloxacin and linezolid for infections.
Advice request: continue carboplatin OR change chemo OR which tests to determine next steps.
What might be causing increase in bilirubin? Please suggest.
Now SGOT- 390, SGPT 190, Bilirubin 24. Patient on weekly Herceptin (150mg)+ carboplatin (100mg) dose since 2 weeks. Taking ciprofloxacin and linezolid for infections.
Advice request: continue carboplatin OR change chemo OR which tests to determine next steps.
What might be causing increase in bilirubin? Please suggest.
posted on
Fri, 3 May 2013
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Mon, 6 May 2013
Answered on
Mon, 6 May 2013
Last reviewed on
Sorry to hear about your problem.
The most probable cause for rise in bilirubin is metastasis to the liver. This can explain the rise in the enzymes and bilirubin. This can be confirmed by a simple ultrasound of the abdomen.
Metastatic breast cancer can be quite challenging to treat. Carboplatin and herceptin are some of the chemotherapy agents used to treat such a disease and do not lead to a rise in liver enzymes.
As the patient is HER positive, it is prudent to continue herceptin. If the patient's disease is progressing on carboplatin, you can discuss the change of this agent with your oncologist.
Hoping for the best.
The most probable cause for rise in bilirubin is metastasis to the liver. This can explain the rise in the enzymes and bilirubin. This can be confirmed by a simple ultrasound of the abdomen.
Metastatic breast cancer can be quite challenging to treat. Carboplatin and herceptin are some of the chemotherapy agents used to treat such a disease and do not lead to a rise in liver enzymes.
As the patient is HER positive, it is prudent to continue herceptin. If the patient's disease is progressing on carboplatin, you can discuss the change of this agent with your oncologist.
Hoping for the best.
I find this answer helpful
Simple obstruction of CBD- Common Bile Duct is the reason for increase in billirubin.
ERCP or PTC may help if ur doctor feel u fit for it.
Sincerely,
Dr. Vinay Kumar,
Senior Consultant Oncology and Radiotherapy
ERCP or PTC may help if ur doctor feel u fit for it.
Sincerely,
Dr. Vinay Kumar,
Senior Consultant Oncology and Radiotherapy
I find this answer helpful
Simple obstruction of CBD- Common Bile Duct is the reason for increase in billirubin.
ERCP or PTC may help if ur doctor feel u fit for it.
Sincerely,
Dr. Vinay Kumar,
Senior Consultant Oncology and Radiotherapy
ERCP or PTC may help if ur doctor feel u fit for it.
Sincerely,
Dr. Vinay Kumar,
Senior Consultant Oncology and Radiotherapy
I find this answer helpful
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer.
For a more detailed, immediate answer, try our premium service
[Sample answer]
Related questions you may be interested in
Recent questions on Breast cancer
Loading Online Doctors....