my wife of 80 years has had both knees replaced 8 years ago, She has had trouble with arthrtiis, bladder infections, just got over a nasty cold, but now has aching knees ,wrists & sholders. She's over weight and now has trouble walking and has insomnia. 'Aching all over' seems to be much worse in the past 10 days. She has no temperature . What's wrong?