Hello, my mother has medullary carcinoma of breast PR Is –ev ..ER is –ev,,, HER2 is –ev I would like to consult with you to help me to find out the best way of treatment that you would suggest. C.E.F a lonely(for six cycles) or Adjuvant therapy ( C.E.F + paclitaxel ) (CEF for Three cycles and paclitaxel for Three cycle). In addition my mother age is 61years old and Centinel Lymph node: not involved Tumor size: 3x2x2CM Lymphovascular invasion: not seen Preneural invasion: not seen Skin : free of tumor. All resected margin are free of tumor. Centinel Lymph node: not involved.