Hello, doctor. I am giving you context/history/back so you have relevant info that I believe is important for you to know. Please read all first, but my main question for you is about sertraline, I know sertraline can be taken day or night . . . but is it better for being "upbeat", engaged, etc. to take it during the day? The dose we have is 50 mg 1x day given first in April . . . my husbandd never was "depressed" . . . I do my husband's dialysis at home daily and we are doing very well and we are so involved/researched back when and ongoing for "food as medicine" . . . at nearly 6 years on dialysis my husband is really a case study in success . . . married 40 years, love makes for health . . . but about the sertraline . . . he's got the blues (he's an artist and was still teaching art-making at 78 years of age (I'm 63) and artists are typically blue -- he is professor emeritus of fine arts and I am a doctor of education -- both retired when dialysis came in our lives -- we were patients of the chief of nephrology at Johns Hopkins (no docs in our neck of the woods) helped my husband and so we traveled to Johns Hopkins a couple of times a year -- and he tweaked some meds and put in a right renal artery stent (my husband takes very few meds) and that beloved doc said my husband wouldn't need dialysis but in case of emergency get a local nephrologist and within 3 months the doc up here put my husband on dialysis -- our Johns Hopkins nephrologist was stunned when we told him the local nephrologist got him on dialysis (just "business/profit"). i was trained in home hemodialys and we didn't have a generator when storm sandy hit and we had to go to the clinic for a while but we've gotten a generator and our trusted docs -- the Johns Hopkins nephrologist, our beloved pulmonogist (my husband had TB as a teen and has well-managed COPD) and our cardio (no heart issues) and the vascular doc who did all my husband's AV (buttonhole) fistula back when and also the peritoneal catheter -- they all love my husband (and me1) and said peritoneal dialysis was okay (my husband feared peritonitis but we are so careful to avoid infection) and all has/is going splendidly. For the time being we are "homebound" patients since a physical therapist early in summer set my husband back since she worked him so harshly -- but now we have a great home doc and nurse and PT/OT therapists and they are helping my husband so wonderfully. So . . . . . about the sertraline? Thank you for bearing with this narrative. Thank you for your thoughts about the sertraline. All best to you and yours. (And please keep this private and don't give our e-mail out.) Thanks again.