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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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High Bilirubin Levels. What Does It Mean? Severe Weight Loss

Hello Doctor,
My brother has lost 4-5 kgs weight in last 2-3 months. He is 34 years old.
He has undergone many tests like endoscopy, Complete Blood count, Thyroid, stool test for blood loss, blood sugar test and ultrasonography. All results are normal.
Today he underwent Liver function test (2 of the parameters are above reference range). Results are as follows (reference range given in bracket):

S. BIluribin - 1.5 (0 - 1)
D. Biluribin - 0.3 (0 - 0.2)
SGOT - 15 (6 - 40)
SGPT - 17 (8 - 37)
S. Alkali - 102 (36 - 140)
Total protein - 8.3 (6 - 8.5)
S. Albumin - 4.4 (3.5 - 5)
Globulin - 3.9 (2.5 - 5)
AG Ratio - 1.1 (1 - 1.4)

S. Biluribin and D. Biluribin are slightly above reference range. What does it indicate. Please advise. Are there any more tests needed?

Thanks in advance.
Thu, 23 May 2013
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General & Family Physician,  's  Response
Hello.As you say S.Bilirrubin and D.Bilrrubin are slightly above reference range. The most common causes of increased bilirubin levels are liver,
vesicle or pancreas diseases.For Liver and vesicle, abdomen ultrasound is
correct additional test but for pancreas is necessary to request a computed axial tomography(CAT scan).Your doctor,probably,will request because
a person with weight loss and increased bilirubin levels,pancreas disease
must be rule out.
I wish you good health.
(In case the answer would have been useful please indicate this)

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Pathologist and Microbiologist,  Dr. Shailja Puri's  Response
Hello and welcome to HCM,

Your liver function tests are within normal limits except for a mild elevation of total and direct bilirubin.
However, this mild increase is not of any consequence when all other parameters are within normal limits. The liver seems to function normally.
However, the cause of loss of weight over past 2-3 months has to be investigated.
A complete clinical examination needs to be done.
Weight loss over a short period of time is alarming. It can occur due to conditions like tuberculosis, malignancy, etc.
Is there associated cough, expectoration, etc. This is indicative of tuberculosis.
If there are any symptoms related to any organ system.
Further investigations pertaining to that organ system need to be done.

Thanks and take care
Dr Shailja P Wahal
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High Bilirubin Levels. What Does It Mean? Severe Weight Loss

Hello.As you say S.Bilirrubin and D.Bilrrubin are slightly above reference range. The most common causes of increased bilirubin levels are liver, vesicle or pancreas diseases.For Liver and vesicle, abdomen ultrasound is correct additional test but for pancreas is necessary to request a computed axial tomography(CAT scan).Your doctor,probably,will request because a person with weight loss and increased bilirubin levels,pancreas disease must be rule out. I wish you good health. (In case the answer would have been useful please indicate this)