Mom, 56years, right leg amputated (chronic diabetic) with known case of pulmonary edema recovered last year, is now diagnoised high bp 200/100 and creatinine level 2.00. presently under ramipiril 5mg bd, arkamin bd, zytanix 2.5mg and lasix 40mg od, nebicard 5mg od and digoxin half a tablet. thyronorm 0.25 tsh level(3rd gen) 7.2. what cud be the cause and suggested remedy?