Hi, everyday around 1 p.m. and 3 p.m., my face turns really bright red, mostly on my cheeks and they get really hot. Then in about another hour or less, I get a bad headache. I take Lotensin and Amlodipine daily for high blood pressure, Eliquis for blood thinner, Zoloft, Vicoprofen, Requip, and Savella, and have taken these for quite some time. Even though I take the Requip for leg pain, I have been having excessive leg pain for the past week and a half. The hot/red face has been going on for over 2 weeks now. Thank you, Cindi Poulson