** Thanks for contacting with your health concern 1. As you are pregnant and under the supervision of your physician so remain under constant observation and do not change or stop any drug without first consulting with your attending doctor, I at most can let you know about general rules to be followed while prescribing to pregnant patients: i. In early pregnancy [as in your case], avoid any medications except Iron, calcium, paracetamol, and antacids. ii. No newly introduced drugs should be given during pregnancy, only those drugs, whose safety has been established over years, should be prescribed. iii. Avoid antithyroid, cytotoxic drugs, anticoagulant drugs. iv. In late pregnancy, do not give aspirin [bleeding tendency], sulpha [neonatal jaundice], tetracyclines [stains teeth], choloromycetin [gray baby syndrome], aminoglycosides [deafness] 2. since klebsiella organisms are resistant to multiple antibiotics [as urine culture already done], and closely resemble K. pneumonia and three common clinical manifestations of UTIs in pregnancy are asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis, so one can give the following permitted antibiotics [get a second opinion from gynecologist]: - Third generation cephalosporins with other measures like plenty of water and fluids, and watch for vaginal candidiasis during antibiotic treatment. PS. remember without treatment, untreated UTI in pregnancy is associated with preterm delivery, intrauterine growth retardation, low birth weight, maternal hypertension, pre-eclampsia, and anemia, and if patients’ condition is not improving despite adequate and appropriate use of antimicrobials, further investigations for underlying predisposing factors are necessary BUT Prophylactic antibiotic is indicated for recurrent UTI.