I have ME for 21 years, I am bedbound 75% of time & the rest of time housebound. At the moment I take ketamine & methadone for chronic pain,have tried fentanyl & dehidrocodine for years but they stopped working,hence ketamine & methadone & diazepam since January this year. I take other meds for the other conditions that this relentless illness throws at me. Any ideas for pain relief as nothing seems to work for me, I think I have a high tolerance for pain meds so any suggestions would be greatly appreciated.Also skin is extremely sensitive,cannot wear normal clothes or have bed clothes touching me as it s too painful. Honestly any suggestions that my dr & I could explore would be greatly received as nobody really knows what to do with me. Hope to hear back from you soon, thanks,. From someone at the end of their tether......