Wart is caused by human papilloma virus (HPV) and is transmitted by sexual intercourse. It is a very resistant kind of infection. Relapse is common very after treatment. Creams, surgery and laser treatments are available but no treatment guarantees cure. Sometimes it resolves spontaneously without treatment. You have already undergone laser treatment. It has again relapsed. Treatment is not required if it not causing any problem. Advice for you 1. Imiquimod 5% cream – apply it only on wart which is outside anus and penis head. Apply onto fingertip and rubbed onto clean, dry, wart area until cream vanishes, once daily, three times per week at bed time. Wash off next morning with soap and water. Apply very small amount. Use this for 16 weeks continuously. But do not use it if you are pregnant or planning to conceive. After 16 weeks of use, if wart does not disappear then consult your doctor of other treatment option. Non-treatment is an option for asymptomatic warts. 2. Take high protein diet such as eggs, pulses and meat to enhance immunity 3. Use condom during sex. Also ask your wife to use female condom to prevent genital wart Advice for your wife 1. No treatment is required 2. Take high protein diet such as eggs, pulses and meat to enhance immunity 3. You can go for laser treatment if you are cosmetically anxious. For this, consult a dermatologist who are doing laser treatment of wart Thanks