Thanks for asking. few queries Any associated weight gain/ hairloss/ tiredness/ constipation? *Any history of recurrent fever / thyroid pain/ eye pain / bulging eye ball/ tiredness? *Periods- is it regular? *How is your quality of life? *Any family history of thyroid disease/ goiter or thyroid malignancy? any history of thigh or arm muscle weakness/ hump/striae? few tests needs to be done before weight loss regimen. To exclude hormonal disorder. TSH/free T4/ calcium /fasting lipid profile/ ALT / Calcium/phosphorus/HBA1C currently approved weight loss drugs by FDA 1) tab orlistat taken orally it decreased fat absorption from gut. Average weight loss is 3-4kg per month if the person s diet predominantly fat based. 2) inj. liraglutide it s a GLP 1 analogue approved once a day injection taken , it decreased appetite. average weight loss 4-5 kg in guidelines. But in my experience I have seen 10 kg in one month. Hope I have answered your question. If you have any further questions I will be happy to help. Thankyou. Wish you good health first of all treatment for hypothyroidism is only required if TSH is more than 10 and you don t just increase dose with symptoms but only with increased TSH values kindly taper the dose to check whether you need the drug