Hello and welcome Thanks for posting your query medicines are there but I would suggest you to focus on diet and exercise i would like further informations to guide you better like #your age #complete medical history since how long you have been diagnosed as hypothyroid disease # are you on medicine if yes then since when ? #Your height and weight because medicines can be prescribed when your BMI increases by more than 30 In my opinion you should follow these guidelines strict dietary restrictions and make a chart of what you are eating and follow it very religiously. 30 to 45 minutes daily exercises, slowly start with brisk walking or jogging and gradually you can build your stamina. You should also include muscle building exercises for additional benefits. Have plenty of fruits vegetables and dietary fibers Take plenty of fluids 3 to 4 liters a day. Medicines are not recommended in your case. But if you wish to try them under strict medical supervision, you can discuss about appetite suppressant drugs like phentermine or sibutramine and lipase inhibitors like orlistat with your local doctor. These are not available over the counter I hope you will find my response informative and helpful Best wishes