I have suffered with bi-polar II disorder and fibromyalgia for about 20 years. I have been on Seroquel for about 15 years but recently suffered a back injury and I am worried because I know that Seroquel does not mix well with Opiods and I have been placed on 5mg of Vicodin 2 x day while they get my MRI and other test. I had recently spoke with my Phyciatrist about trying to switch from Seroquel to another drug due to weight gain that I believe is from the Seroquel. The Doctor tried to switch me to Latuda and while I was coming off the Seroquel, I lost 4 pounds. I was unable to stay on the Latuda because I could not sleep. I had always taken Seroquel and Ambien at bedtime and found that I had to take both to get sleep. If I forgot to fill one I would not sleep. I was so sleep deprived, I had to go back on the Seroquel and Ambien because my mental state was deteriorating! I guess my question is how can I come off the Seroquel and get my body back in line to sleep without it. If I can t do that, I can t change medications and the Seroquel is really not helping. I have been stuck in depression most of the past 20 years. Doing good just means staying out of the hospital. Now with the back injury, I am having major lower back pain and spasms, I am concerned with them prescribing me pain medication but am suffering and need something. I would appreciate your advise on this. Thank you.