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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Can Syphilis Be Treated?

Hi, I came to know syphilis in the month of March 2017. i had treatment then started testing vdrl and tpha. They were coming positive again and again. In the month of May i tested TPHA it came 1/680 again tested TPHA in September it cam 1/160 positive. I want to know that is it decreasing and when vdrl will go negative ?
Sat, 11 Aug 2018
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General Surgeon,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

As well known and must be explained by your consultant, Penicillin G is the gold standard therapy for syphilis management.

The four fold decline in TPHA titer (as in your case 160 from 680) is considered well response to the therapy.

The total negative report may take many more months say even 24 months in certain cases. So do not panic regarding the same and continue current medications with regular follow up with your consultant.

Thanks.

Regards.
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How Can Syphilis Be Treated?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. As well known and must be explained by your consultant, Penicillin G is the gold standard therapy for syphilis management. The four fold decline in TPHA titer (as in your case 160 from 680) is considered well response to the therapy. The total negative report may take many more months say even 24 months in certain cases. So do not panic regarding the same and continue current medications with regular follow up with your consultant. Thanks. Regards.