My understanding is that immunotherapy up through the early 2000 s was used as a secondary therapy. In treating lymphoma the strategy was to knock down the cancer with chemo, and then follow up with an immunotherapy such as monoclonal antibody therapy (Ritoxin). However, now it s a first line therapy. My understanding is that the success rate increased from about 30 percent to 60-70% when the antibody therapy was used to deliver a chemo toxin or radioactive nuclei. Has the effectiveness increased that much? My cousin is being treated for uterine cancer. They are starting with Ritoxin; then chemo and radiation. I ve asked why not start by delivering chemo and radiation via monoclonal antibody therapy. Don t know if it is a solid tumor, probably. I m speculating that traditional chemo and radiation might be more effective if a solid tumor. Thanks, I m trying to help, Bob