My husband is in the process of being diagnosed with Wegeners Granulomatosis, Rheumatologist is pretty confident, but wanted biopsy and more blood work before officially making the diagnosis. She upped his Prednisone from 20 MG to 60 MG, 5 days later, still no improvements noticed. His immune system is already compromised because he does not have a spleen. Will not having a spleen make a differnce on how the steriod works? Many WG patients I have talked to (in a support forum), have felt a difference with a day. Any help would be appreciated!