study says the effect of higher dose and increased frequency (twice yearly) of albendazole-ivermectin therapy for W bancrofti ( causes filaria) and found that it resulted in complete microfilarial clearance, as well as a more sustained clearance than that resulting from standard-dose albendazole-ivermectin treatment. note: Microfilaremia rates increase with age through childhood and early adulthood, although clinical infection may not be apparent. study also suggest that the reduction in microfilarial intensity may result from hormonal changes associated with female reproduction age .