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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Long Does Metoprolol Stay In The System?

I don t understand the half life of a drug. MY husband has been on metoprolol succinate er for about 5 months taking 25mg 2x s a day. He is now being weaned off the drug. 1 pill a day for a week then half a pill for another week. How long will it take for this medicine to leave his system completely?
Tue, 11 Jul 2017
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General & Family Physician,  's  Response
Hi,
Thanks for posting in HCM.
I understand your concern.
Metoprolol is absorbed over a large part of the intestine.
It is extensively metabolised and only about 5% of an oral dose and 10% of an intravenous dose is excreted in unchanged form via the kidneys.
The mean elimination half-life of metoprolol is 3 to 4 hours.
Hope the information provided would be helpful.
All the best.
Regards,
Dr.Ashakiran.S.,
MBBS., MD.
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How Long Does Metoprolol Stay In The System?

Hi, Thanks for posting in HCM. I understand your concern. Metoprolol is absorbed over a large part of the intestine. It is extensively metabolised and only about 5% of an oral dose and 10% of an intravenous dose is excreted in unchanged form via the kidneys. The mean elimination half-life of metoprolol is 3 to 4 hours. Hope the information provided would be helpful. All the best. Regards, Dr.Ashakiran.S., MBBS., MD.