I have been on 75 mg of Irbesartan, taken at 8 PM daily (I am a non-dipper) for 10 days, after weaning off of Bystolic because I could not sleep. I do not have heart disease and am in not in heart failure. I am female, active, 71 and in pretty good health. I liked the Irbesartan until a few days ago, when my BP and HR began rising as much as 30 points within hours of taking the Irbesartan. This never happened to me with my 2.5 mg of Bystolic. How can I safely wean off of the Irbesartan? I have read on Rxlist, Drugs.com and other sites that it can be taken safely with Bystolic. So if I want to start adding Bystolic to stop this from happening at night while I am backing off of Irbesartan is that okay?