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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How To Stabilize The ALT Level Which Is Shooting From 42 To 95?

Hello I recently had a blood test taken and my ALT had risen from 42 in December to 95 at the end of January. Are you able to advise how long it takes before ALT returns to normal. I was also taking Trazodone which can elevate ALT. I stopped taking this two weeks ago. Many thanks
Mon, 8 Jun 2015
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Cardiologist,  's  Response
The liver damage (hepatotoxicity) with trazadone is idiosyncratic, it means it is not related to the dose and cannot be predicted. You did a very wise thing of withdrawing it, as per recommendations the drug shouldn't be ever used back. Try taking an alternative drug. As for liver ALT you can repeat after 3 weeks and should have normalised by than. However the above side effect is very rare, make sure that no other drugs, herbal preparation or even a binge of alcohol was taken at that point of time. Regards Dr priyank mody
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How To Stabilize The ALT Level Which Is Shooting From 42 To 95?

The liver damage (hepatotoxicity) with trazadone is idiosyncratic, it means it is not related to the dose and cannot be predicted. You did a very wise thing of withdrawing it, as per recommendations the drug shouldn t be ever used back. Try taking an alternative drug. As for liver ALT you can repeat after 3 weeks and should have normalised by than. However the above side effect is very rare, make sure that no other drugs, herbal preparation or even a binge of alcohol was taken at that point of time. Regards Dr priyank mody