Hello and welcome, evening primrose oil helps to control some symptoms of estrogen loss. It will not cause any harm. Fluoxetin is an anti depressant and is used for the treatment of depression as well as menopausal syndrome. So this is the reason for prescription. However, if the symptoms persist I suggest that she take a short course of Hormone replacement therapy if it is not contraindicated. She may also try phyto estrogens present in green leafy veges, and soyabeans. Protein powders containing phytoestrogens are also available and they can be taken with milk. Please discuss this with your doctor. She may even be weaned off from anti depressants if she responds to estrogen. Hope this was helpful. Thanks for using HCM. Feel free to ask any more questions that you may have. Dr Madhuri Bagde Consultant Obstetrician and Gynecologist