I have a good x for ospehna. Have not started it yet but also have ra and take Remicade infusions once a month and on plaquinil two times a day. Also get allergy shots bi weekly. And take allergy meds daily. I am concerned about drug interactions and weight gain. I have a hard time keeping my weight down now.i have used Estrada and primarily before resulting in large nodules in my breasts. I am hesitant to start the ospehna.