I have been off Arimidex for one year and one- half after taking it for four years and four months. My breast cancer was found early but I took the Arimidex. I had lots of problems taking the medicine mainly achy joints , soreness in my legs, it still hurts to rub my legs. The main problem was memory loss. That is why I stopped short of five years. My memory has not got any better. My doctor said it was not my medicine. I asked her,"are you telling me that know one tells you they have memory loss"? She said ,"well they do but the research on the drug does not show that". I felt like a Ginny Pig. I think more studies need to be done