I have been taking losartan/hctz 100-12.5 once a day for years. It seems as if when I was taking the name brand HYZAAR, my blood pressure was under better control. Once it was changed to generic, my blood stay higher 138-161/86-95. Also how high does your pressure need to be in order to get really worried while on medicine. I also take metoprolol tartrate 100 mg 2 times a day. Will pravastatin elevate blood pressure?