I have taken up until about June Calan SR 240 twice a day if I did not forget a dose the DR. I saw at that time told me when he looked at my chart an see that I was taking that med. and my legs were swollen that the calan was the problem why would not one but several DR. tell me to take it over a period of 20 to 30 years do you not advise them as the manufacturer of it not to have a person take and change to something after a few years I have been unwell now for about 6 months and do not know really going on with my body in Dec 8-9-10 I thought I had the Flu was so sick I wished I could don't know but have not been well since 2nd. trip to DR. coming up soon a spec.